Blar i forfatter "Johansen, David"

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    • The Ambivalence of Connexin43 Gap Peptides in Cardioprotection of the Isolated Heart against Ischemic Injury 

      Falck, Aleksander Tank; Lund, Bjarte Aarmo; Johansen, David; Lund, trine; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)
      The present study investigates infarct-reducing effects of blocking ischemia-induced opening of connexin43 hemichannels using peptides Gap19, Gap26 or Gap27. Cardioprotection by ischemic preconditioning (IPC) and Gap peptides was compared, and combined treatment was tested in isolated, perfused male rat hearts using function and infarct size after global ischemia, high-resolution respirometry of ...

    • Cardioprotection : focus on Gap Junctions, Hemichannels and Mitochondria 

      Johansen, David (Doctoral thesis; Doktorgradsavhandling, 2012-05-04)
      I studiene har vi undersøkt hjerteceller og isolerte hjerter under forhold som ligner på hjerteinfarkt. Denne kunnskapen brukte vi videre til å redusere hjerteinfarkt på rottehjerter. Vi har sett på effekten av hjerteinfarkt på mitokondrier og spesielle kanaler i hjertet som heter gap junctions og halvkanaler. Vi har vist at ved å holde spesielle halvkanaler lukket noen få minutter etter ett ...

    • Coronary flow reserve in pregnant rats with increased left ventricular afterload 

      Songstad, Nils Thomas; Serrano, Maria; Sitras, Vasilis; Johansen, David; Ytrehus, Kirsti; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-09)
      Background Coronary flow reserve (CFR) is used as a measure of coronary endothelial function. We investigated the effect of increased afterload on CFR of pregnant and non-pregnant rats. Methods Afterload increase in Wister rats (both pregnant and non-pregnant) was achieved by the infusion of angiotensin II (Ang II) for ~10 days or by subjecting them to transverse aortic constriction (TAC) ...

    • Effect of Transverse Aortic Constriction on Cardiac Structure, Function and Gene Expression in Pregnant Rats 

      Songstad, Nils Thomas; Johansen, David; How, Ole-Jakob; Kaaresen, Per Ivar; Ytrehus, Kirsti; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Background: There is an increased risk of heart failure and pulmonary edema in pregnancies complicated by hypertensive disorders. However, in a previous study we found that pregnancy protects against fibrosis and preserves angiogenesis in a rat model of angiotensin II induced cardiac hypertrophy. In this study we test the hypothesis that pregnancy protects against negative effects of increased ...

    • Gender differences in hearts subjected to decreased NO-production and elevated blood pressure 

      Kildal, Simon; Ludvigsen, Stian; Norvik, Jon Viljar; Johansen, David; Ytrehus, Kirsti (Master thesis; Mastergradsoppgave, 2016-10-31)
      Hypertension is one of the most important risk factors for heart failure in the general population. Hypertensive heart failure is associated with heart failure with preserved ejection fraction (HFpEF). Women have an increase proportion of HFpEF compared to men. Endothelial dysfunction thereby reduced NO production is proposed to play an important role in the pathophysiology of HFpEF. A suggested ...